Connection of poly (Propylene imine) dendrimer to curcumin and investigation into anti-cancer effects of its products

Mohammadpour, Keyhan; Salahvarzi, Sabah; Dadgar, Zeynab

doi:10.26655/AJNANOMAT.2020.4.8

Document Type : Original Article

Authors

¹ Department of Chemistry, Faculty of Science, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran

² Department of biology, Faculty of Science, Arak University, Arak, Iran

https://doi.org/10.26655/AJNANOMAT.2020.4.8

Abstract

The dendrimers are the macromolecules that branch out from the same nuclear and they finally reach the same central nucleus. The solubility of the dendrimer is strongly affected by the surface groups. These compounds are the ideal carriers for biomedical applications. One of the oldest identified dendrimer is poly (propylene imine) dendrimer (denoted as PPI dendrimer). The present study consists of two sections. In the first section, the interaction between the (PPI) dendrimer with different molar ratios of curcumin was investigated at the presence or absence of the ultrasonic waves. In the second section, the anti-cancer effects of this compound on BRC-9 cell line (of breast cancer cells) were investigated with the help of 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay.

Graphical Abstract

Keywords

References

[1]. Markman J.L., Rekechenetskiy A., Holler E., Ljubimova J.Y. Adv Drug Deliv Rev., 2013, 65:1866

[2]. Xu R., Zhang G., Mai J., Deng X., Segura-Ibarra V., Wu S., Shen J., Liu H., Hu Z., Chen L., Huang Y., Koay E., Huang Y., Liu J., Ensor J. E., Blanco E., Liu X., Ferrari M., Shen H., Nat Biotechnol., 2016, 34:414

[3]. Chittasupho C., Anuchapreeda S., Sarisuta N., Eur J Pharm Biopharm, 2017, 119:310

[4]. Manzur A., Oluwasanmi A., Moss D., Curtis A., Hoskins C. Pharmaceutics, 2017, 9:39

[5]. Myung J.H., Tam K.A., Park S.J., Cha A., Hong S. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2016, 8:223

[6]. Rosen J.E., Chan L., Shieh D.B., Gu F.X. Nanomedicine, 2012, 8:275

[7]. Jennifer M., Maciej W., Journal of Biomaterials and Nanobiotechnology, 2013, 4:53

[8]. Petros R.A., De Simone J.M. Nat Rev Drug Discov, 2010, 9:615

[9]. Kesharwani P., Xie L., Banerjee S., Mao G., Padhye S., Sarkar F.H., Iyer A.K., Colloids Surf B Biointerfaces, 2015, 136:413

[10]. Salahvarzi S., Shamaie S., ORGANIC CHEMISTRY RESEARCH., 2019, 5:202

[11]. Caminade A.-M., Turrin a.C.-O. Journal of Materials Chemistry B., 2014, 2:4055

[12]. Agrawal A., Kulkarni S., International Journal of Research and Development in Pharmacy and Life Sciences, 2015, 4:1700

[13]. Tsai H.C., Imae

Asian Journal of Nanoscience and Materials

Connection of poly (Propylene imine) dendrimer to curcumin and investigation into anti-cancer effects of its products

References

References

Volume 3, Issue 4
October 2020
Pages 340-350

Connection of poly (Propylene imine) dendrimer to curcumin and investigation into anti-cancer effects of its products

References

References

Volume 3, Issue 4October 2020Pages 340-350

Volume 3, Issue 4
October 2020
Pages 340-350