TY - JOUR ID - 69788 TI - Promising anti-inflammatory bio-efficacy of saponin loaded silver nanoparticles prepared from the plant Madhuca longifolia JO - Asian Journal of Nanoscience and Materials JA - AJNM LA - en SN - 2645-775X AU - Sharma, Mukti AU - Yadav, Saurabh AU - Srivastava, Man AU - Ganesh, Narayanan AU - Srivastava, Shalini AD - Department of Chemistry, Faculty of Science, Dayalbagh Educational Institute, Agra, 282005, India AD - Jawaharlal Nehru Cancer Hospital & Research Centre, Bhopal, 462001, India Y1 - 2022 PY - 2022 VL - 5 IS - 4 SP - 313 EP - 326 KW - Madhuca longifolia KW - Green synthesis KW - Saponin loaded silver nanoparticles Enhanced anti-inflammatory activity DO - 10.26655/AJNANOMAT.2022.4.5 N2 - Phyto-compounds facilitated synthesis of nanoparticles has created an exceptional impact in the formation of nanoparticles and is used for the synthesis of modern nano drugs. Ignorance about phytochemical composition particularly knowledge of the bio-active principle of medicinal plant restricts the demonstration of the real picture of the enhancement of any bio-efficacy. The present communication scientifically established anti-inflammatory bio-efficacy in seeds of the folk plant Madhuca longifolia and its significant enhancement by bio-active principle (saponin) loaded silver nanoparticles (S@AgNps). A family of four saponins has been explored quantified (3.59%) and characterized (Micro Mass ESI-TOF MS spectra). Synthesis of S@AgNps has been conducted in a green single step and thoroughly characterized. In- vivo assessment of anti-inflammatory bio-efficacy has been carried out using carrageenan induced hind paw edema in Swiss albino mice model. Anti-inflammation bio-efficacy of native seed extract (15 mg/kg/bw) was found 46.84% which was further elevated and further rose to 56.10% by saponin at considerable low optimized dose (1.5 mg/kg/bw). Anti-inflammatory bio-efficacy was further successfully enhanced to (70.99%) by S@AgNps, almost close to that of reference drug (Diclofenac sodium; 76.42%). Saponin loaded silver nanoparticles (S@AgNps) prepared from the seed extract of the plant M. longifolia seem to be an ideal candidate for the development of complimentary herbal nanomedicine for anti-inflammation. UR - https://www.ajnanomat.com/article_69788.html L1 - https://www.ajnanomat.com/article_69788_e3c33c89653c0dc4b6433e044eb659c8.pdf ER -