TY - JOUR ID - 131085 TI - Toxicity testing of indocyanine green and fluorodeoxyglucose conjugated iron oxide nanoparticles with and without exposure to a magnetic field JO - Asian Journal of Nanoscience and Materials JA - AJNM LA - en SN - 2645-775X AU - Unak, Perihan AU - Hepton, Rachel AU - Harper, Max AU - Yasakci, Volkan AU - Pearce, Gillian AU - Russell, Steve AU - Aras, Omer AU - Oguz, Akin AU - Wong, Julian AD - Ege University, Institute of Nuclear Sciences, Department of Nuclear Applications, Bornova Izmir, 35100, Turkey AD - Aston University, School of Life and Health Sciences, Aston Triangle, Birmingham, B4 7ET, United Kingdom AD - Aston University, School of Engineering and Applied Sciences, Aston Triangle, Birmingham, B4 7ET, United Kingdom AD - Memorial Sloan Kettering Cancer Centre, Department of Radiology, New York, USA AD - University Hospital Singapore, Cardiothoracic and Vascular Surgery Department, Singapore Y1 - 2021 PY - 2021 VL - 4 IS - 3 SP - 229 EP - 239 KW - Fluorodeoxyglucose Indocyanine green Iron oxide nanoparticles Magnetic effect NIC KW - H7272 cells DO - 10.26655/AJNANOMAT.2021.3.5 N2 - Iron nanoparticles (MNPs) are known to induce membrane damage and apoptosis of cancer cells. In our study we determined whether FDG coupled with iron oxide magnetic nanoparticles can exert the same destructive effect on cancer cells. This research study presents data involving NIC-H727 human lung, bronchus epithelial cells exposed to conjugated fluorodeoxyglucose conjugated with iron-oxide magnetic nanoparticles and indocyanine green (ICG) dye (FDG-MNP-ICG), with and without the application of a magnetic field. Cell viability inferred from MTT assay revealed that FDG-MNPs had no significant toxicity towards noncancerous NIC-H727 human lung, bronchus epithelial cells. However, percentage cell death was much higher using a magnetic field, for the concentration of FDG-MNP-ICC used in our experiments. Magnetic field was able to destroy cells containing MNPs, while MNPs alone had significantly lower effects. Additionally, MNPs alone in these low concentrations had less adverse effects on healthy (non-target) cells. UR - https://www.ajnanomat.com/article_131085.html L1 - https://www.ajnanomat.com/article_131085_9bb275f23fb7fadf6da9e01e4d253e87.pdf ER -