%0 Journal Article %T Effects of fluorodeoxyglucose magnetic nanoparticles on NCI-H727 and SH-SY5Y cancer cells %J Asian Journal of Nanoscience and Materials %I Sami Publishing Company %Z 2645-775X %A Unak, Perihan %A Budiyo, Rumbidzai Cheryl %A Horsnzky, Alex %A Yasakci, Volkan %A Pearce, Gillian %A Russell, Steve %A Aras, Omer %A Oguz, Akin %A Wong, Julian %D 2021 %\ 01/01/2021 %V 4 %N 1 %P 53-66 %! Effects of fluorodeoxyglucose magnetic nanoparticles on NCI-H727 and SH-SY5Y cancer cells %K Magnetic nanoparticles Fluorodeoxyglucose SH %K SY5Y NCI %K H727 Spheroids %R 10.26655/AJNANOMAT.2021.1.5 %X < p>< p>We present a report regarding the cytotoxic effects of iron-based magnetic nanoparticles conjugated with fluorodeoxyglucose (FDG-mNPs) on the viability of NCI-H727 and SH-SY5Y cancer cells. MTT assays were performed to determine cell viability in treated cancer cells grown under standard 2D culture conditions. FDG-mNP concentrations of 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL decreased mean cell viability of NCI-H727 cells to 92.5%, 82.9%, and 75% respectively. FDG-mNPs was also shown to have a detrimental effect on the viability of SY5Y cells: a decrease of 5.7%, 18.6%, and 36.4% was found for SY5Y cells treated with 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL concentrations of FDG-mNPs, respectively. When NCI-H727 and SH-SY5Y cancer cells were grown as 3D spheroids, morphology was visibly changed and the number of viable cells was decerased in spheroids treated with FDG-mNPs compared with untreated spheroids. The results of our study demonstrated that FDG-mNP has toxic effects on NCI-H7272 and SY5Y cancer cells, and we conclude that conjugated FDG-mNPs are promising in the development of clinical applications for the destruction of cancer cells. %U https://www.ajnanomat.com/article_120615_b4c9eff4f9cab9619bf83734dd49b86c.pdf