Highly effective synthesis of 3, 4-dihydropyrimidin-2 (1H)-ones using pyridinium-N-sulfonic acid bisulfate as a dual-functional catalyst

Document Type: Original Article

Authors

Department of Chemistry, Payame Noor University, PO Box 19395-3697 Tehran, Iran

Abstract

Acidic ionic liquid pyridinium-N-sulfonic acid bisulfate ([Py-SO3H][HSO4]) has effectively catalyzed the production of 3, 4-dihydropyrimidin-2 (1H)-ones via the condensation reaction of the arylaldehydes with β-ketoesters and urea under solvent-free conditions. Due to the dual-functionality of [Py-SO3H][HSO4] (bearing acidic and basic sites), it was highly effective and general catalyst for the reaction. Additionally, an attractive mechanism for the dual-functionality of the catalyst was proposed.

Graphical Abstract

Highly effective synthesis of 3, 4-dihydropyrimidin-2 (1H)-ones using pyridinium-N-sulfonic acid bisulfate as a dual-functional catalyst

Keywords

Main Subjects


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Articles in Press, Accepted Manuscript
Available Online from 08 April 2019
  • Receive Date: 25 January 2019
  • Revise Date: 18 February 2019
  • Accept Date: 18 February 2019