@article { author = {Unak, Perihan and Budiyo, Rumbidzai and Horsnzky, Alex and Yasakci, Volkan and Pearce, Gillian and Russell, Steve and Aras, Omer and Oguz, Akin and Wong, Julian}, title = {Effects of fluorodeoxyglucose magnetic nanoparticles on NCI-H727 and SH-SY5Y cancer cells}, journal = {Asian Journal of Nanoscience and Materials}, volume = {4}, number = {1}, pages = {53-66}, year = {2021}, publisher = {Sami Publishing Company}, issn = {2645-775X}, eissn = {2588-669X}, doi = {10.26655/AJNANOMAT.2021.1.5}, abstract = {< p>< p>We present a report regarding the cytotoxic effects of iron-based magnetic nanoparticles conjugated with fluorodeoxyglucose (FDG-mNPs) on the viability of NCI-H727 and SH-SY5Y cancer cells. MTT assays were performed to determine cell viability in treated cancer cells grown under standard 2D culture conditions. FDG-mNP concentrations of 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL decreased mean cell viability of NCI-H727 cells to 92.5%, 82.9%, and 75% respectively. FDG-mNPs was also shown to have a detrimental effect on the viability of SY5Y cells: a decrease of 5.7%, 18.6%, and 36.4% was found for SY5Y cells treated with 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL concentrations of FDG-mNPs, respectively. When NCI-H727 and SH-SY5Y cancer cells were grown as 3D spheroids, morphology was visibly changed and the number of viable cells was decerased in spheroids treated with FDG-mNPs compared with untreated spheroids. The results of our study demonstrated that FDG-mNP has toxic effects on NCI-H7272 and SY5Y cancer cells, and we conclude that conjugated FDG-mNPs are promising in the development of clinical applications for the destruction of cancer cells.}, keywords = {Magnetic nanoparticles Fluorodeoxyglucose SH,SY5Y NCI,H727 Spheroids}, url = {https://www.ajnanomat.com/article_120615.html}, eprint = {https://www.ajnanomat.com/article_120615_b4c9eff4f9cab9619bf83734dd49b86c.pdf} }